Insulin Oogenesis

Here, we report that insulin signaling modulates collective BC movement during Drosophila oogenesis. Supporting the involvement of Insulin pathway, we demonstrate that compromising Insulin-like Receptor InR levels in BCs, inhibits their migration. Furthermore, we show that canonical Insulin signaling pathway components participate in this

INSULIN OOGENESIS AND FOLLICULOGENESIS Primordial follicles. The formation of primordial follicles occurs during the latter half of pregnancy in humans and ruminants, but immediately after birth in rodents. The postnatal mouse ovary is mainly populated by primordial follicle each composed of a meiotically arrested primary oocyte surrounded by

The chemosensory neurons ASJ modulate oogenesis onset through the insulin-like peptide ILP INS-6. In contrast, other sensory neurons, the olfactory neurons AWA, regulate food type-dependent differences in C. elegans fertilization rates, but not onset of oogenesis. AWA modulates fertilization rates at least partly in parallel to insulin

Insulininsulin-like growth factor signaling IIS within adult adipocytes remotely controls oocyte production at distinct stages of oogenesis. The PI3KAkt1 axis in adipocytes promotes germline stem cell maintenance via SGG, Drosophila GSK-3, and early germline survival via an unidentified Akt1 target.

Insulin signaling regulates various aspects of physiology, such as glucose homeostasis and aging, and is a key determinant of female reproduction in metazoans. That insulin signaling is crucial for female reproductive health is clear from clinical data linking hyperinsulinemic and hypoinsulinemic co

The highly conserved insulininsulin-like growth factor pathway is a prominent and multifaceted actor in the regulation of oogenesis. In Drosophila , insulin-like peptides bind and activate a single receptor tyrosine kinase, the insulin receptor InR Nassel et al., 2015 .

We examined the dynamics of insulin signaling activity during oogenesis by assessing phospho-AKT levels in early follicles and stage 14 oocytes. AKT is active during the early stages of oogenesis but was barely detected in stage 14 oocytes Figures 4G and 4H. Collectively, these data indicate that insulin signaling is significantly reduced in

3 insulin regulation of oogenesis and ovarian development Oocytes are terminal gametes, thus their quality is the principal determinant of early embryonic survival, establishment and maintenance of pregnancy, fetal development, and the acquisition of several birth defects Gilbert, Macaulay, amp Robert, 2015 Zhang amp Smith, 2015 .

Insulin signalling in insects, as in mammals, regulates various physiological functions, such as reproduction. However, the molecular mechanism by which insulin signals orchestrate ovarian stem cell proliferation, vitellogenesis, and oviposition remains elusive. In insect oogenesis, the continuous division of ovarian stem cells is

while illustrating insulin's unique role in specific reproductive processes. KEYWORDS ERK, insulin, oocyte development, oogenesis, PCOS, PI3KAKT, steroidogenesis quotWe propose that insulin is a key, evolutionarily ancient regulator of female reproduction.quot 1 INTRODUCTION The successful propagation of a species requires proper oocyte